No Confirmation of Pestivirus RNA in Human Virus Vaccines

Genotypes of pestivirus RNA detected in live virus vaccines for human use.

Live virus vaccines for human use, 29 monovalent vaccines against measles, mumps, rubella or polio, eight polyvalent vaccines against measles-mumps-rubella and one bacterial polyvalent vaccine against Streptococcus pneumoniae, were tested by reverse transcriptase-nested PCR for the presence of petivirus or pestivirus RNA. Twenty-four samples were selected from European manufacturers, ten were f...

Use of human diploid cell MRC - 5, for production of Measles and Rubella virus vaccines

No Evidence of Murine Leukemia Virus-Related Viruses in Live Attenuated Human Vaccines

BACKGROUND The association of xenotropic murine leukemia virus (MLV)-related virus (XMRV) in prostate cancer and chronic fatigue syndrome reported in previous studies remains controversial as these results have been questioned by recent data. Nonetheless, concerns have been raised regarding contamination of human vaccines as a possible source of introduction of XMRV and MLV into human populatio...

Screening and confirmation of human immunodeficiency virus type 1 infection solely by detection of RNA.

Diagnosis of human immunodeficiency virus (HIV) infection by antibody-based testing allows for some recently infected individuals to be falsely assessed as non-infected. Since such individuals often have high viral loads and are capable of transmitting HIV, it is an imperative public health need to identify these individuals. We investigated the feasibility and capability of a diagnostic algori...

Prophylactic Human Papilloma Virus Vaccines

Human papillomaviruses are the primary etiologic agents of cervical cancer. Thus, cervical cancer and other Human papillomavirus associated malignancies might be prevented by Human papillomavirus vaccines. Currently, two Human papillomavirus L1 Virus -Like Particle vaccines namely Gardasil quadrivalent (Merck) and CervarixTM bivalent (GlaxoSmithKline) are widely marketed internationally. These ...